Nitromed has been in trouble for several years now. They're a perfect example of a dog that caught a car: a company that was demolished by actually getting its drug on the market. No one wanted to...

So it was green fluorescent protein after all! We can argue about whether this was a pure chemistry prize or another quasi-biology one, but either way, the award is a strong one. So, what is the stuff and what's it do? Osamu Shimomura discov...

I'll be out doing non-scientific things all day, so the march of progress is going to have to lurch along without me for a bit. I'll see everyone on Monday! And if you're in need of something to waste a bit of time on, this site will make your sense...

There's a commentary in the December issue of Nature Chemistry asking why our field has been comparatively slow to adopt web-based technologies like arXiv and GenBank: "New web-based models of scholarly communication have made a significant impact in...

Year-end rushing around has left me little time for blogging last night or this morning. But a discussion with a colleague the other day leads me to ask a quick question of the readership: has there ever, in your view, been a realistic depiction of a...

Readers may remember the incident a couple of years ago where a paper was published claiming the synthesis of some very odd-looking 12-membered ring compounds. Prof. Manfred Christl of the University of Würzburg noticed something odd about this...

I'm continuing my look at Bernard Munos' paper on the drug industry, which definitely repays further study (previous posts here, here, and here). Now for some talk about money - specifically, how much of it you'll need to find a new drug. The Munos...